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Heart Diseases (Research)

Volume 929: debated on Thursday 7 April 1977

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asked the Secretary of State for Education and Science if she will publish in the Official Report, in tabular form, details of the various research projects into coronary heart and cardio-vascular diseases which are receiving support from public funds together with the location of the establishment at which each project is carried out and the total amount of financial support being provided for each project.

I understand from my right hon. Friend the Secretary of State for Social Services that his Department is supporting the following projects:

ESTABLISHMENT, SUBJECT AND TOTAL COST
£'000s
Royal Devon and Exeter Hospital
Heart block survey in the Devon clinical area45·0
University of Exeter
Institute of Biometry and Community Medicine. Ongoing studies include:*
i. Cardiac rehabilitation.
ii. Analysis of results of heart block/brady cardia survey
iii. Analysis of mortality in heart block/brady cardia survey
iv. Cardiac infarction register.
Brompton Hospital
Co-operative study of congenital heart disease in England and Wales18·4
London School of Hygiene and Tropical Medicine
Chronic Disease Control Unit Studies ongoing include:
i. Identification of high blood pressure in the community54·5
ii. Co-operative study of high blood pressure in the community, Borehamwood
iii. High blood pressure; public attitudes and knowledge.
St. Mary's Hospital Medical School
Heart disease prevention study314·6
West Middlesex Hospital
Investigation of patients suffering from transient ischaemic attacks14·7
Institute for Social Studies in Medical Care
Programme of studies in General practice. Ongoing studies include:
i. Pilot study of public attitudes to and knowledge of hypertension.*
ESTABLISHMENT, SUBJECT AND TOTAL COST
£'000s
St. Thomas's Hospital
Social Medicine and Health Services Research Unit. Ongoing studies include:
i. Blood pressure level in children.*
Newcastle General Hospital
The prognostic significance of ventricular arrhythmias in the first 24 hours of myocardial infarction20·3
University of Newcastle
The prevalence and interrelationship of hypothyroidism and ischaemic heart disease36·6
University of Nottingham
Acute myocardial infarction, trial of home versus hospital treatment88·4
City General Hospital, Stoke on Trent
Rehabilitation after myocardial infarction76·8
* Projects not separately costed.
In addition the Department is supporting 27 projects in its Locally Organised Research scheme at an estimated total cost of £235,297.Information in respect of projects supported by the Medical Research Council is not readily available in the form requested. Projects in the Council's own establishments with the estimated expenditure for 1976–77 are listed below:

ESTABLISHMENT, SUBJECT AND ESTIMATED EXPENDITURE 1976–77 £'000
Blood Pressure Unit
Development of Methods for measuring plasma corticosteroids, rennin, angiotensin, vasopressin and ACTH66
Studies of the effects of infusion of injection of corticosteroids and injection of rennin, angiotensin and vasopressin in man and animals71
Clinical studies of diagnosis treatment and incidence of hypertension haemodynamic electrolyte corticosteroid rennin peptide techniques and systems analysis123
Studies on animals of renal, malignant and docla induced hypertension using haemodynamic electrolyte corticosteroid, rennin, angiotensin and vasopressin techniques34
Studies of non-hypertensive electrolyte and endocrine disorders using haemodynamic electrolyte corticosteroid, rennin, angiotensin and vasopressin techniques20
Clinical Research Center
Morphometric study of pulmonary oedema in congestive cardiac failure4
Correlation of biochemical data with vascular disease in maturity onset diabetes19
ESTABLISHMENT, SUBJECT AND ESTIMATED EXPENDITURE 1976–77 £'000s
Relationship between ambient temperature and mortality of myocardial infarction and cerebral vascular accidents3
Clinical Pharmacology Unit
Autopharmacology of disease states: vasospasm of intracranial arteries occurring in patients with subarachnoid haemorrhage16
Clinical and Population Cytogenetics Unit
Computer analysis of ECGS in chromosomally abnormal individuals20
Epidemiology Unit (South Wales)
Factors involved in cardiovascular disease, including platelet function12
Randomised controlled trials of aspirin in the prevention of myocardial infarction20
MRC-DHSS Epidemiology and Medical Care Unit North wick Park Hospital
Prediction and pathogenesis of thrombotic disease79
MRC trial of treatment in mild/moderate hypertension36
The underlying metabolic lesion in familial hypercholesterolaemia58
MRC Laboratories Jamaica, University of the West Indies
Assessment of studies on cardiovascular disease in Jamaica4
Lipid Metabolism Unit
Regression of atherosclerosis in familial hypercholesterolaemia22
Trans-capillary transport of human lipoprotein22
Pneumoconiosis Unit
Human Biology: Assessment of normal exercise performance8
Human Biology: Use of diseases and other agents to study physiological processes8
Tuberculosis and Chest Diseases Unit
Survey of blood pressure in children14
Further projects at Medical Research Council establishments and supported by Council grants elsewhere relevant to cardiovascular disease with the estimated expenditure for 1976–77 are listed below:

ESTABLISHMENT, SUBJECT AND ESTIMATED EXPENDITURE 1976–77
£'000s
Clinical Research Centre
Experimental Microvascular Surgery and Cryosurgery16
Non-Invasive Blood Flow Measurement by Ultrasonic Means in the Aorta and Superficial Vessels30
Ballistocardiagraphy using simple portable low cost equipment7
ESTABLISHMENT, SUBJECT AND ESTIMATED EXPENDITURE 1976–77
£'000s
Ambulatory Monitoring by miniature Tape Recorders of EKG, EEG and BP54
Computer based records for Hypertension Clinics5
Use of Whole Body Counter for long term Metabolic Tracer Studies and total body Potassium Measurements24
Clinical Pharmacology Unit
Development of Methods for Monitoring Drug Therapy in individual patients: Digoxin in Heart Disease25
Welsh National School of Medicine, Cardiff
Prospective study of the late Morbidity of Post-operative deep vein thrombosis4
Royal Infirmary and Associated Hospitals, Glasgow
Platelet behaviour in normal pregnancy and in pregnancies complicated by hypertension6
Guy's Hospital Medical School, London
Myocardial function and oxygen consumption, with particular reference to anaesthetics and heart rate2
King's College Hospital Medical School, London
Study of the pathogenesis, prophylaxis, treatment and sequelae of deep vein thrombosis41
University of Nottingham
Maternal and foetal renin angiotensin systems with especial reference to pregnancy hypertension9
Arterial Disease and Thrombosis15
University of Oxford
Prospective study of smoking and carboxyhaemoglobin levels in relation to ischaemic heart disease and lung cancer5
Projects being carried out by Medical Research Council external scientific staff with the estimated expenditure for 1976–77 are listed below:

ESTABLISHMENT, SUBJECT AND ESTIMATED EXPENDITURE 1976–77
£'000
Dr. J. A. Heady, Department of Clinical Epidemiology, Royal Free Hospital School of Medicine
Co-operative trial of clofibrate in the primary prevention of ischaemic heart disease15
Professor J. P. Shillingford, Division of Cardiology, Royal Postgraduate Medical School
The effect of drugs on electrocardiographic surface mapping haemodynamic changes and enzyme release in patients with special emphasis on cardiogenie shock2
ESTABLISHMENT, SUBJECT AND ESTIMATED EXPENDITURE 1976–77
£'000s
Programmed stimulation of the heart to elucidate the mechanics of arrhythmias and to enable the correct treatment to be instituted in patients2
Studies on the role of lyssomes in cardiac hypoxia, enzyme release in hypoxic rat heart and the modification of these biochemical changes by drugs3
Dr. J. C. F. Poole, Sir William Dunn, School of pathology, University of Oxford
Em chromosomal, biochemical and platelet studies on cultivated arterial smooth muscle cells6
Tumour production by established cell lines from cultivated rabbit arterial cells6
Electron microscop-studies on cell junctions and other structural features of atherosclerotic plaques normal arterial smooth muscle cells and organised mural thrombi6
Dr. C.J. Miller, Caribbean Epidemiology Centre, Trinidad
Trinidad cardiovascular survey12
Research grants made by the Council and estimated expenditure for 1976–77 are as follows:

University of Aberdeen
The "tight binding" of Plasma lipoprotein in human atherosclerotic lesions and its relation to lipid accumulation4
University of Birmingham
Central nervous control of the circulation36
Investigation of hyperlipidaemia in relation to cardiovascular disease17
University of Bristol
The structure of Human serum very-low-density apolipoproteins5
Phosphorylation of contractile proteins as a mechanism for the regulation of cardiac contractility4
Phosphorylation and dephosphorylation of contractile proteins as a mechanism for regulation of cardiac contractility10
Direct measurement of intracellular sodium activity and PH in cardiac muscle cells5
Bristol General Hospital
Investigation of some aspects of the measurement of blood flow using ultrasound13
Papworth Hospital, Cambridge
Pathology of the cardiac conduction tissue in artificially paced patients1
ESTABLISHMENT, SUBJECT AND ESTIMATED EXPENDITURE 1976–77
£'000s
University of Cambridge
Effects of drugs and mechanical parametres on the ionic currents generating the cardiac action potential2
Welsh National School of Medicine, Cardiff
Prospective study of the late morbidity of post-operative deep vein thrombosis4
University of Edinburgh
The relationship between lipid metabolism and dysrhythmias during Myocardial ischaemia and infarction28
Imperial College of Science and Technology London
Arterial and fluid mechanism, and air way fluid and particle mechanisms44
King's College Hospital Medical School London
Study of the parthogenesis, prophylaxis, treatment and sequelae of deep vein thrombosis41
London School of Hygiene and Tropical Med London
Exercise in leisure-time in relation to coronary heart disease32
Primary prevention of ischaemic heart disease. Co-operative trial using clofibrate15
Middlesex Hospital Medical School London
Synthesis of low density lipoproteins in normal and hypercholesterolacmic guinea pigs5
Mechanism of control of aldosterone production by cells of the zona glomerulosa of rat, beef, and human adrenals46
Royal Free Hospital School of Medicine London
Regional variation in cardiovascular disease in relation to water quality and other environmental factors19
Royal Postgraduate Medical School London
Therapy and function in myocardial infarction22
St. Thomas's Hospital Medical School London
Community based of moderate Hypertension1
Function tests of plasma triglyceride metabolism with reference to investigation of ischaemic heart disease12
Quantitative study of lipoproteins in human arterial biopsies and in plasma3
University College London London
Eletrophysiology of muscarinic acetylcholine receptors1
University College Hospital Medical School London
Involvement of the adrenal cortex in pathogenesis of hypertensive vascular disease77
ESTABLISHMENT, SUBJECT AND ESTIMATED EXPENDITURE 1976–77
£'000s
University of Manchester
Changes in the properties or arterial smooth muscle in normotensive and hypertensive rats4
To define the properties required of prosthesis to replace medium sized arteries3
University of Nottingham
Maternal and foetal renin angiotensin systems with especial reference to pregnancy hypertension9
Arterial disease and thrombosis15
University of Oxford
Prospective study of smoking and carboxyhaemoglobin levels in relation to ischaemic heart disease and lung cancer5
Analysis of the effects of prolonged beta-adrenoceptor blockade7
Mode of initiation of impulses in arterial chemoreceptors2
Development of laminar-flow artificial heart valves for use without anticoagulant therapy23
Electrical actions of drugs affecting the rhythms and contractility of the heart16
Radcliffe Infirmary Oxford
Cardiovascular fluid dynamics28
University of Southampton
Development of acetylenic alkylating agents for thiolase as inhibitors of cholesterol biosynthesis3
Caribbean Epidemiology Centre Pan American Health Organisation (W.H.O.) Washington USA
Epidemiological study of myocardial ischaemia, high-density-lipoprotein and other coronary risk-factors in Trinidad23
University of Edinburgh
Electrophysiological investigation of sensory transmission at the carotid chemoreceptors4
University of Glasgow
Pilot study of MRC treatment trial for mild Hypertension23
Royal infirmary and Associated Hospitals Glasgow
Platelet behaviour in normal pregnancy and in pregnancies complicated by hypertension6
University of Hull
Myocardial metal concentrations and sudden death from heart disease3
Discrimination and instructional control of variations in cardiovascular activity6
ESTABLISHMENT, SUBJECT AND ESTIMATED EXPENDITURE 1976–77
£'000s
St. Bartholomew's Hospital Medical College London
Carotid baro—and chemoreceptor reflexes affecting regional vascular resistence and capillary filtration coefficient1
Effects of ventilation on the interactions between arterial chemoreceptor and baroreceptor vascular reflexes1
Cardiothoracic Institute London
Attempted identification of population of children that will subsequently develop hypertension20
Normal and diseased metabolism of heart muscle24
St. George's Hospital Medical School London
Effect of coronary risk factors on 1(isoprenaline induced lesions in rat heart 2(morphology of arterial endothelium6
Guy's Hospital Medical School London
Mechanisms of arterial disease in a diabetic population sample16
Diagnosis of internal carotid artery insufficiency by ultrasonic angiology12
Myocardial function and oxygen consumption, with particular reference to anaesthetics and heart rate2
Information is not available in respect of work supported by universities and hospital medical schools.