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Depression

Volume 457: debated on Monday 19 February 2007

To ask the Secretary of State for Health (1) what research her Department has commissioned on the cost-effectiveness of routine screening of populations known to be at high risk of depression; (112019)

(2) what studies her Department has commissioned comparing the efficacy of different models of therapy offered to those suffering from depression.

The Department has not commissioned any national research and development programme work in these areas. We provide funding for research and development programmes which support policy and provide the underpinning evidence needed for quality improvements and service development in the national health service, but these are devolved to and managed by NHS organisations.

NHS research and development programmes which are funded this way include the NHS health technology assessment programme, which has commissioned the following projects:

A pragmatic randomised controlled trial to evaluate exercise prescription as a treatment for depression.

Clinical effectiveness and cost of repetitive transcranial magnetic stimulation versus electro-convulsive therapy in severe depression: a multi-centre randomised controlled trial and economic analysis.

Randomised trial of fluoxetine and cognitive-behavioural therapy versus fluoxetine alone in adolescents with persistent major depression.

Antidepressant drug therapy versus a community-based psychosocial intervention for the treatment of moderate postnatal depression: a pragmatic randomised controlled trial.

Psychological interventions for postnatal depression - randomised controlled trial and economic evaluation.

Randomised controlled trial to determine the cost-effectiveness of fluoxetine for mild to moderate depression with somatic symptoms in primary care—threshold for antidepressant treatment.

Folate augmentation of treatment—valuation for depression: randomised controlled trial.

Effectiveness of counselling, cognitive behavioural therapy and general practitioner care for depression in general practice.

A randomised controlled trial to evaluate the efficacy and cost-effectiveness of counselling with patients with chronic depression and anxiety.

The clinical effectiveness and cost-effectiveness of computerised cognitive behaviour therapy for depression and anxiety.

Computerised cognitive behaviour therapy for depression and anxiety update: a systematic review and economic evaluation.

Clinical and cost-effectiveness of electro-convulsive therapy for depressive illness, schizophrenia, catatonia and mania; systematic reviews and economic modelling studies.

A rapid and systematic review and economic evaluation of the clinical effectiveness and cost-effectiveness of newer drugs for treatment of mania associated with bipolar affective disorder.

A randomised controlled trial to compare the cost-effectiveness of tricyclic antidepressants, selective serotonin re-uptake inhibitors and lofepramine.