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Brain Tumours

Volume 460: debated on Wednesday 9 May 2007

To ask the Secretary of State for Health how much funding has been provided by her Department for research into brain tumours in 2006-07. (129877)

The Department funds research to support policy and to provide the evidence needed to underpin quality improvement and service development in the national health service. The Department’s national research programme spend on projects related to brain tumour in 2006-07 is £868,000. This figure includes expenditure in two areas where the focus is on paediatric oncology as a whole. It excludes expenditure from the research and development allocations made annually to NHS providers. That information is not held centrally.

To ask the Secretary of State for Health if she will list the brain tumour studies being supported by her Department; how much funding has been provided to each study by her Department; and how many (a) children and (b) adults are taking part in these studies. (129878)

The information available is shown in the table.

National Cancer Research Network (NCRN) supported brain tumour studies—Adult brain tumour patients

Title

Research Funder

Status

Recruitment

BR12: Temozolomide vs PCV chemotherapy in the treatment of recurrent malignant glioma

Cancer Research UK (CR-UK)/Medical Research Council (MRC)

Recruiting

351

BR 14: A randomised controlled trial of temozolomide as adjuvant and/or concurrent treatment in anaplastic (WHO grade III) glioma

European Organisation for Research and Treatment of Cancer (EORTC)/Schering Plough

In set-up

0

Primary chemotherapy with temozolomide vs. radiotherapy in patients with low grade gliomas with stratification for genetic 1p loss: a phase III study

EORTC/ Schering Plough

In set-up

0

No Radiotherapy versus Whole Brain Radiotherapy for 1 to 3 Brain Metastases from Solid Tumor after Surgical Resection or Radiosurgery. A Randomized Phase III Trial

EORTC

In set-up

0

Phase III Trial comparing Conventional Adjuvant Temozolomide with Dose Intensive Temozolomide in Patients with Newly Diagnosed Glioblastoma

EORTC

In set-up

0

BR11: Adjuvant procarbazine, CCNU and vincristine chemotherapy in patients with highly anaplastic oligodendroglioma

MRC

Closed, in follow-up

368

Multicentre, Phase II Study of Carboplatin pre-irradiation in patients with primary glioblastoma multiforme following biospy

Closed, in follow-up

25 (closed early)

Childhood brain tumour patients

Hyperfractionated accelerated radiotherapy (HART) with chemotherapy (cisplatin, CCNU, vincristine) for metastatic (M1-3) Medulloblastoma

CR-UK

Recruiting

18

A Prospective randomised controlled trial of hyperfractionated versus conventionally fractionated radiotherapy in standard risk medulloblastoma

CR-UK

Recruiting

18

Phase II study of the combination of Cisplatin + Temozolomide in malignant glial tumours in children and adolescents at diagnosis or in relapse

CR-UK

Recruiting

15

Cooperative Multicentre Study For Children And Adolescents With Low Grade Glioma

CR-UK

Recruiting

111

Magnetic Resonance Spectroscopy of Brain Tumours

CR-UK

Recruiting

48

Magnetic Resonance Spectroscopy of Brain Stem Tumours

CR-UK

Recruiting

7

An in depth study over time on the effect of child and parent factors on the perceived quality of life of children treated for a brain tumour

Samantha Dickson Research Trust Brain Tumour UK

Recruiting

47

Phase I Studies of TARCEVA (erlotinib Hydrochloride, OSI-774) as Single Agent in Children with Refractory and Relapsed Malignant Brain Tumours and in Combination with Irradiation in Newly Diagnosed Brain Stem Glioma

CR-UK

Recruiting

0

CNS 1992 04 (Infant Brain Tumours) Use of high-field strength MR derived biomarkers in prostate cancer: Potential for improved cancer staging and prognostication

CR-UK

Closed, in follow-up

213

Study of Paediatric Low Grade Gliomas

CR-UK

Closed, in follow-up

798

Treatment of children with newly diagnosed diffuse pontine gliomas using conventional radiotherapy and high dose tamoxifen

CR-UK

Closed, in follow-up

31

SIOP Intracranial Germ Cell TumoursI

CR-UK

Closed, in follow-up

137

Comparison of Hair regrowth in children with localised PNETs of the posterior fossa (medulloblastoma) treated with surgery followed by radiotherapy or chemotherapy and radiotherapy

CR-UK

Closed, in follow-up

75

The Department’s allocation to the NCRN in 2006-07 is £14.5 million. It is not possible to say what part of this support funding is spent on individual projects.

Details of a number of other non-NCRN studies supported from the allocations made by the Department to national health service research active organisations can be found on the National Research Register at

www.dh.gov.uk/research