The re-use of rabbits in pyrogen tests is permitted under the Animals (Scientific Procedures) Act 1986. Consent for re-use of animals in procedures is generally conditional upon the animal having suffered no significant adverse effects as a consequence of the first use, and its not having been subjected to any intervention which compromises its suitability as a subject for the second or subsequent protocol. Authority to re-use any animal that has experienced significant adverse effects in its previous use is unlikely to be granted.
Home Office records show that four establishments licensed under the Animals (Scientific Procedures) Act 1986 have completed statistical returns during the last three years reporting pyrogen tests on rabbits.